About Lutropin subunit beta
Lutropin subunit beta (LHB) is a protein
from Homo sapiens identified by UniProt accession
P01229, 141 residues long.
MolForge cross-references it against 0 known binders and
270 disease associations.
Target properties
| Protein name | Lutropin subunit beta |
|---|
| UniProt accession | P01229 |
|---|
| Gene | LHB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 141 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (270)
Diseases linked to this target (Open Targets).
- Leydig cell hypoplasia due to LHB deficiency · score 0.59
- hypogonadotropic hypogonadism 23 with or without anosmia · score 0.56
- testosterone measurement · score 0.27
- squamous cell lung carcinoma · score 0.19
- endometrial cancer · score 0.18
- blood protein measurement · score 0.16
- human Chorionic Gonadotropin measurement · score 0.14
- head and neck squamous cell carcinoma · score 0.11
- Kallmann syndrome · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01229-F1 | alphafold | PREDICTED | 84.52 | — |
Amino-acid sequence (141 residues)
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN TTICAGYCPT MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV SFPVALSCRC GPCRRSTSDC GGPKDHPLTC DHPQLSGLLF L
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