About Parathyroid hormone
Parathyroid hormone (PTH) is a protein
from Homo sapiens identified by UniProt accession
P01270, 115 residues long.
MolForge cross-references it against 0 known binders and
1,114 disease associations.
Target properties
| Protein name | Parathyroid hormone |
|---|
| UniProt accession | P01270 |
|---|
| Gene | PTH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 115 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1114)
Diseases linked to this target (Open Targets).
- Familial isolated hypoparathyroidism · score 0.72
- hypoparathyroidism, familial isolated 1 · score 0.65
- calcium measurement · score 0.46
- familial hypoparathyroidism · score 0.43
- neurodegenerative disease · score 0.40
- blood phosphate measurement · score 0.39
- familial isolated hypoparathyroidism due to impaired PTH secretion · score 0.37
- primary hyperparathyroidism · score 0.35
- multiple sclerosis · score 0.34
- Parkinson disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01270-F1 | alphafold | PREDICTED | 72.14 | — |
Amino-acid sequence (115 residues)
MIPAKDMAKV MIVMLAICFL TKSDGKSVKK RSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ
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