About Pro-glucagon
Pro-glucagon (GCG) is a protein
from Homo sapiens identified by UniProt accession
P01275, 180 residues long.
MolForge cross-references it against 0 known binders and
910 disease associations.
Target properties
| Protein name | Pro-glucagon |
|---|
| UniProt accession | P01275 |
|---|
| Gene | GCG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 180 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (910)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.26
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.23
- medulloblastoma · score 0.23
- serum albumin measurement · score 0.17
- leukocyte count · score 0.16
- apolipoprotein A 1 measurement · score 0.16
- neutrophil count · score 0.16
- hepatocellular carcinoma · score 0.14
- myeloid white cell count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01275-F1 | alphafold | PREDICTED | 68.95 | — |
Amino-acid sequence (180 residues)
MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK
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