Pancreatic polypeptide prohormone (PPY)

About Pancreatic polypeptide prohormone

Pancreatic polypeptide prohormone (PPY) is a protein from Homo sapiens identified by UniProt accession P01298, 95 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.

Target properties

Protein name	Pancreatic polypeptide prohormone
UniProt accession	P01298
Gene	PPY
Organism	Homo sapiens
Length	95 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (181)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.16
blood protein measurement · score 0.10
hyperinsulinism due to INSR deficiency · score 0.05
hyperinsulinism due to glucokinase deficiency · score 0.05
exercise-induced hyperinsulinism · score 0.04
hyperproinsulinemia · score 0.04
triglyceride measurement · score 0.04
Hypoglycemia · score 0.03
reticulocyte count · score 0.03
neuroendocrine neoplasm · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01298-F1	alphafold	PREDICTED	76.63	—

Amino-acid sequence (95 residues)

MAAARLCLSL LLLSTCVALL LQPLLGAQGA PLEPVYPGDN ATPEQMAQYA ADLRRYINML TRPRYGKRHK EDTLAFSEWG SPHAAVPREL SPLDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards