About Insulin
Insulin (INS) is a protein
from Homo sapiens identified by UniProt accession
P01308, 110 residues long.
MolForge cross-references it against 0 known binders and
700 disease associations.
Target properties
| Protein name | Insulin |
|---|
| UniProt accession | P01308 |
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| Gene | INS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 110 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (700)
Diseases linked to this target (Open Targets).
- hyperproinsulinemia · score 0.76
- diabetes mellitus, permanent neonatal 4 · score 0.75
- MODY · score 0.73
- maturity-onset diabetes of the young type 10 · score 0.72
- type 1 diabetes mellitus · score 0.69
- permanent neonatal diabetes mellitus · score 0.66
- monogenic diabetes · score 0.56
- transient neonatal diabetes, dominant/recessive · score 0.51
- diabetes mellitus · score 0.49
- maturity-onset diabetes of the young · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01308-F1 | alphafold | PREDICTED | 52.90 | — |
Amino-acid sequence (110 residues)
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC SLYQLENYCN
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