About Insulin-like growth factor 2
Insulin-like growth factor 2 (IGF2) is a protein
from Homo sapiens identified by UniProt accession
P01344, 180 residues long.
MolForge cross-references it against 0 known binders and
903 disease associations.
Target properties
| Protein name | Insulin-like growth factor 2 |
|---|
| UniProt accession | P01344 |
|---|
| Gene | IGF2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 180 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (903)
Diseases linked to this target (Open Targets).
- Silver-Russell syndrome due to a point mutation · score 0.69
- Beckwith-Wiedemann syndrome · score 0.65
- Silver-Russell syndrome · score 0.63
- type 1 diabetes mellitus · score 0.45
- maturity-onset diabetes of the young type 10 · score 0.42
- genetic disorder · score 0.41
- diabetes mellitus, permanent neonatal 4 · score 0.39
- lean body mass · score 0.37
- isolated hemihyperplasia · score 0.37
- hyperproinsulinemia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01344-F1 | alphafold | PREDICTED | 59.02 | — |
Amino-acid sequence (180 residues)
MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK
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