Gastrin (GAST)

About Gastrin

Gastrin (GAST) is a protein from Homo sapiens identified by UniProt accession P01350, 101 residues long. MolForge cross-references it against 0 known binders and 538 disease associations.

Target properties

Protein name	Gastrin
UniProt accession	P01350
Gene	GAST
Organism	Homo sapiens
Length	101 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (538)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
breast adenocarcinoma · score 0.23
peptic ulcer disease · score 0.15
gonorrhea · score 0.11
neoplasm · score 0.10
MODY · score 0.09
myocardial infarction · score 0.09
type 2 diabetes mellitus · score 0.09
melanoma · score 0.08
gastric neuroendocrine tumor, well differentiated, low or intermediate grade · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01350-F1	alphafold	PREDICTED	64.88	—

Amino-acid sequence (101 residues)

MQRLCVYVLI FALALAAFSE ASWKPRSQQP DAPLGTGANR DLELPWLEQQ GPASHHRRQL GPQGPPHLVA DPSKKQGPWL EEEEEAYGWM DFGRRSAEDE N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards