Interleukin-1 beta (IL1B)

About Interleukin-1 beta

Interleukin-1 beta (IL1B) is a protein from Homo sapiens identified by UniProt accession P01584, 269 residues long. MolForge cross-references it against 0 known binders and 2,263 disease associations.

Target properties

Protein name	Interleukin-1 beta
UniProt accession	P01584
Gene	IL1B
Organism	Homo sapiens
Length	269 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (2263)

Diseases linked to this target (Open Targets).

cryopyrin-associated periodic syndrome · score 0.54
gout · score 0.53
pericarditis · score 0.50
Muckle-Wells syndrome · score 0.50
juvenile idiopathic arthritis · score 0.49
immune system disease · score 0.47
Antisynthetase syndrome · score 0.45
Familial cold urticaria · score 0.43
systemic juvenile idiopathic arthritis · score 0.40
familial Mediterranean fever · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01584-F1	alphafold	PREDICTED	76.23	—

Amino-acid sequence (269 residues)

MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL GGTKGGQDIT DFTMQFVSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards