About Immunoglobulin J chain
Immunoglobulin J chain (JCHAIN) is a protein
from Homo sapiens identified by UniProt accession
P01591, 159 residues long.
MolForge cross-references it against 0 known binders and
271 disease associations.
Target properties
| Protein name | Immunoglobulin J chain |
|---|
| UniProt accession | P01591 |
|---|
| Gene | JCHAIN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 159 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (271)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.21
- cutaneous melanoma · score 0.18
- multiple myeloma · score 0.18
- endometrial cancer · score 0.16
- low grade glioma · score 0.10
- diabetes mellitus · score 0.10
- isolated agammaglobulinemia · score 0.09
- common variable immunodeficiency · score 0.09
- severe combined immunodeficiency due to CARD11 deficiency · score 0.08
- hyper-IgM syndrome type 2 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01591-F1 | alphafold | PREDICTED | 87.05 | — |
Amino-acid sequence (159 residues)
MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD
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