Immunoglobulin kappa variable 1-33 (IGKV1-33)

About Immunoglobulin kappa variable 1-33

Immunoglobulin kappa variable 1-33 (IGKV1-33) is a protein from Homo sapiens identified by UniProt accession P01594, 117 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Immunoglobulin kappa variable 1-33
UniProt accession	P01594
Gene	IGKV1-33
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.06
esophageal adenocarcinoma · score 0.04
squamous cell carcinoma · score 0.03
ulcerative colitis · score 0.01
idiopathic pulmonary fibrosis · score 0.01
multiple myeloma · score 0.01
systemic lupus erythematosus · score 0.01
Leishmaniasis · score 0.00
colorectal cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01594-F1	alphafold	PREDICTED	91.31	—

Amino-acid sequence (117 residues)

MDMRVPAQLL GLLLLWLSGA RCDIQMTQSP SSLSASVGDR VTITCQASQD ISNYLNWYQQ KPGKAPKLLI YDASNLETGV PSRFSGSGSG TDFTFTISSL QPEDIATYYC QQYDNLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards