Immunoglobulin kappa variable 1-17 (IGKV1-17)

About Immunoglobulin kappa variable 1-17

Immunoglobulin kappa variable 1-17 (IGKV1-17) is a protein from Homo sapiens identified by UniProt accession P01599, 117 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Immunoglobulin kappa variable 1-17
UniProt accession	P01599
Gene	IGKV1-17
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.06
esophageal adenocarcinoma · score 0.04
squamous cell carcinoma · score 0.04
Crohn's disease · score 0.02
idiopathic pulmonary fibrosis · score 0.01
ulcerative colitis · score 0.01
lupus nephritis · score 0.01
Leishmaniasis · score 0.01
atrial fibrillation · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01599-F1	alphafold	PREDICTED	90.26	—

Amino-acid sequence (117 residues)

MDMRVPAQLL GLLLLWFPGA RCDIQMTQSP SSLSASVGDR VTITCRASQG IRNDLGWYQQ KPGKAPKRLI YAASSLQSGV PSRFSGSGSG TEFTLTISSL QPEDFATYYC LQHNSYP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards