Immunoglobulin kappa variable 1-5 (IGKV1-5)

About Immunoglobulin kappa variable 1-5

Immunoglobulin kappa variable 1-5 (IGKV1-5) is a protein from Homo sapiens identified by UniProt accession P01602, 117 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Immunoglobulin kappa variable 1-5
UniProt accession	P01602
Gene	IGKV1-5
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.06
squamous cell carcinoma · score 0.05
esophageal adenocarcinoma · score 0.04
central nervous system cancer · score 0.03
myotonic dystrophy · score 0.03
sebaceous of Jadassohn nevus · score 0.03
Crohn's disease · score 0.02
acute myeloid leukemia · score 0.02
ulcerative colitis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01602-F1	alphafold	PREDICTED	90.50	—

Amino-acid sequence (117 residues)

MDMRVPAQLL GLLLLWLPGA KCDIQMTQSP STLSASVGDR VTITCRASQS ISSWLAWYQQ KPGKAPKLLI YKASSLESGV PSRFSGSGSG TEFTLTISSL QPDDFATYYC QQYNSYS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards