Immunoglobulin kappa variable 2D-40 (IGKV2D-40)

About Immunoglobulin kappa variable 2D-40

Immunoglobulin kappa variable 2D-40 (IGKV2D-40) is a protein from Homo sapiens identified by UniProt accession P01614, 121 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Immunoglobulin kappa variable 2D-40
UniProt accession	P01614
Gene	IGKV2D-40
Organism	Homo sapiens
Length	121 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
ulcerative colitis · score 0.03
infect · score 0.01
infection · score 0.01
neoplasm · score 0.01
Vibrio infectious disease · score 0.00
Zika virus infectious disease · score 0.00
Hepatic steatosis · score 0.00
Liver abscess · score 0.00
glioblastoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01614-F1	alphafold	PREDICTED	90.02	—

Amino-acid sequence (121 residues)

MRLPAQLLGL LMLWVPGSSE DIVMTQTPLS LPVTPGEPAS ISCRSSQSLL DSDDGNTYLD WYLQKPGQSP QLLIYTLSYR ASGVPDRFSG SGSGTDFTLK ISRVEAEDVG VYYCMQRIEF P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards