Immunoglobulin lambda variable 1-40 (IGLV1-40)

About Immunoglobulin lambda variable 1-40

Immunoglobulin lambda variable 1-40 (IGLV1-40) is a protein from Homo sapiens identified by UniProt accession P01703, 118 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Immunoglobulin lambda variable 1-40
UniProt accession	P01703
Gene	IGLV1-40
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.06
squamous cell carcinoma · score 0.05
sebaceous of Jadassohn nevus · score 0.04
esophageal adenocarcinoma · score 0.04
central nervous system cancer · score 0.02
Crohn's disease · score 0.02
ulcerative colitis · score 0.02
idiopathic pulmonary fibrosis · score 0.01
myotonic dystrophy · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01703-F1	alphafold	PREDICTED	89.83	—

Amino-acid sequence (118 residues)

MAWSPLLLTL LAHCTGSWAQ SVLTQPPSVS GAPGQRVTIS CTGSSSNIGA GYDVHWYQQL PGTAPKLLIY GNSNRPSGVP DRFSGSKSGT SASLAITGLQ AEDEADYYCQ SYDSSLSG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards