Immunoglobulin lambda variable 2-8 (IGLV2-8)

About Immunoglobulin lambda variable 2-8

Immunoglobulin lambda variable 2-8 (IGLV2-8) is a protein from Homo sapiens identified by UniProt accession P01709, 118 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Immunoglobulin lambda variable 2-8
UniProt accession	P01709
Gene	IGLV2-8
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
squamous cell carcinoma · score 0.06
Barrett's esophagus · score 0.06
esophageal adenocarcinoma · score 0.03
sebaceous of Jadassohn nevus · score 0.02
Crohn's disease · score 0.02
central nervous system cancer · score 0.02
idiopathic pulmonary fibrosis · score 0.01
myotonic dystrophy · score 0.01
ulcerative colitis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01709-F1	alphafold	PREDICTED	87.10	—

Amino-acid sequence (118 residues)

MAWALLLLTL LTQGTGSWAQ SALTQPPSAS GSPGQSVTIS CTGTSSDVGG YNYVSWYQQH PGKAPKLMIY EVSKRPSGVP DRFSGSKSGN TASLTVSGLQ AEDEADYYCS SYAGSNNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards