T cell receptor beta variable 12-3 (TRBV12-3)

About T cell receptor beta variable 12-3

T cell receptor beta variable 12-3 (TRBV12-3) is a protein from Homo sapiens identified by UniProt accession P01733, 115 residues long. MolForge cross-references it against 0 known binders and 2 disease associations.

Target properties

Protein name	T cell receptor beta variable 12-3
UniProt accession	P01733
Gene	TRBV12-3
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (2)

Diseases linked to this target (Open Targets).

Sepsis · score 0.00
autoimmune polyendocrine syndrome type 1 · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01733-F1	alphafold	PREDICTED	89.55	—

Amino-acid sequence (115 residues)

MDSWTFCCVS LCILVAKHTD AGVIQSPRHE VTEMGQEVTL RCKPISGHNS LFWYRQTMMR GLELLIYFNN NVPIDDSGMP EDRFSAKMPN ASFSTLKIQP SEPRDSAVYF CASSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards