Immunoglobulin heavy variable 1-46 (IGHV1-46)

About Immunoglobulin heavy variable 1-46

Immunoglobulin heavy variable 1-46 (IGHV1-46) is a protein from Homo sapiens identified by UniProt accession P01743, 117 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 1-46
UniProt accession	P01743
Gene	IGHV1-46
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.04
sebaceous of Jadassohn nevus · score 0.02
Crohn's disease · score 0.02
ulcerative colitis · score 0.02
cutaneous lupus erythematosus · score 0.01
idiopathic pulmonary fibrosis · score 0.01
sclerosing cholangitis · score 0.01
esophageal squamous cell carcinoma · score 0.01
Leishmaniasis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01743-F1	alphafold	PREDICTED	91.86	—

Amino-acid sequence (117 residues)

MDWTWRVFCL LAVAPGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTS YYMHWVRQAP GQGLEWMGII NPSGGSTSYA QKFQGRVTMT RDTSTSTVYM ELSSLRSEDT AVYYCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards