Immunoglobulin heavy variable 3-53 (IGHV3-53)

About Immunoglobulin heavy variable 3-53

Immunoglobulin heavy variable 3-53 (IGHV3-53) is a protein from Homo sapiens identified by UniProt accession P01767, 116 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 3-53
UniProt accession	P01767
Gene	IGHV3-53
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.04
sebaceous of Jadassohn nevus · score 0.03
Crohn's disease · score 0.02
Lyme disease · score 0.00
ulcerative colitis · score 0.00
idiopathic pulmonary fibrosis · score 0.00
COVID-19 · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01767-F1	alphafold	PREDICTED	90.72	—

Amino-acid sequence (116 residues)

MEFWLSWVFL VAISKGVQCE VQLVETGGGL IQPGGSLRLS CAASGFTVSS NYMSWVRQAP GKGLEWVSVI YSGGSTYYAD SVKGRFTISR DNSKNTLYLQ MNSLRAEDTA VYYCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards