Immunoglobulin heavy variable 3-33 (IGHV3-33)

About Immunoglobulin heavy variable 3-33

Immunoglobulin heavy variable 3-33 (IGHV3-33) is a protein from Homo sapiens identified by UniProt accession P01772, 117 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 3-33
UniProt accession	P01772
Gene	IGHV3-33
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.05
esophageal adenocarcinoma · score 0.04
sebaceous of Jadassohn nevus · score 0.02
Crohn's disease · score 0.02
ulcerative colitis · score 0.01
idiopathic pulmonary fibrosis · score 0.01
sclerosing cholangitis · score 0.01
prostate carcinoma · score 0.00
visceral Leishmaniasis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01772-F1	alphafold	PREDICTED	90.89	—

Amino-acid sequence (117 residues)

MEFGLSWVFL VALLRGVQCQ VQLVESGGGV VQPGRSLRLS CAASGFTFSS YGMHWVRQAP GKGLEWVAVI WYDGSNKYYA DSVKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards