Immunoglobulin heavy variable 3-7 (IGHV3-7)

About Immunoglobulin heavy variable 3-7

Immunoglobulin heavy variable 3-7 (IGHV3-7) is a protein from Homo sapiens identified by UniProt accession P01780, 117 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 3-7
UniProt accession	P01780
Gene	IGHV3-7
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
squamous cell carcinoma · score 0.06
Barrett's esophagus · score 0.05
esophageal adenocarcinoma · score 0.04
Crohn's disease · score 0.03
osteosarcoma · score 0.03
sebaceous of Jadassohn nevus · score 0.03
rheumatoid arthritis · score 0.03
central nervous system cancer · score 0.02
Acute hepatic failure · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01780-F1	alphafold	PREDICTED	90.86	—

Amino-acid sequence (117 residues)

MELGLSWVFL VAILEGVQCE VQLVESGGGL VQPGGSLRLS CAASGFTFSS YWMSWVRQAP GKGLEWVANI KQDGSEKYYV DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards