Immunoglobulin heavy variable 2-70 (IGHV2-70)

About Immunoglobulin heavy variable 2-70

Immunoglobulin heavy variable 2-70 (IGHV2-70) is a protein from Homo sapiens identified by UniProt accession P01814, 119 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 2-70
UniProt accession	P01814
Gene	IGHV2-70
Organism	Homo sapiens
Length	119 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.05
ulcerative colitis · score 0.03
sebaceous of Jadassohn nevus · score 0.02
esophageal adenocarcinoma · score 0.02
idiopathic pulmonary fibrosis · score 0.02
Crohn's disease · score 0.01
sclerosing cholangitis · score 0.00
cutaneous lupus erythematosus · score 0.00
Lyme disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01814-F1	alphafold	PREDICTED	91.68	—

Amino-acid sequence (119 residues)

MDILCSTLLL LTVPSWVLSQ VTLRESGPAL VKPTQTLTLT CTFSGFSLST SGMCVSWIRQ PPGKALEWLA LIDWDDDKYY STSLKTRLTI SKDTSKNQVV LTMTNMDPVD TATYYCARI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards