Immunoglobulin heavy variable 2-5 (IGHV2-5)

About Immunoglobulin heavy variable 2-5

Immunoglobulin heavy variable 2-5 (IGHV2-5) is a protein from Homo sapiens identified by UniProt accession P01817, 119 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 2-5
UniProt accession	P01817
Gene	IGHV2-5
Organism	Homo sapiens
Length	119 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
infection · score 0.11
infect · score 0.11
Barrett's esophagus · score 0.06
sebaceous of Jadassohn nevus · score 0.05
squamous cell carcinoma · score 0.05
viral disease · score 0.04
esophageal adenocarcinoma · score 0.04
neoplasm · score 0.02
chronic lymphocytic leukemia · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01817-F1	alphafold	PREDICTED	91.49	—

Amino-acid sequence (119 residues)

MDTLCSTLLL LTIPSWVLSQ ITLKESGPTL VKPTQTLTLT CTFSGFSLST SGVGVGWIRQ PPGKALEWLA LIYWDDDKRY SPSLKSRLTI TKDTSKNQVV LTMTNMDPVD TATYYCAHR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards