Immunoglobulin heavy variable 4-39 (IGHV4-39)

About Immunoglobulin heavy variable 4-39

Immunoglobulin heavy variable 4-39 (IGHV4-39) is a protein from Homo sapiens identified by UniProt accession P01824, 125 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 4-39
UniProt accession	P01824
Gene	IGHV4-39
Organism	Homo sapiens
Length	125 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
lymphoid leukemia · score 0.14
infection · score 0.11
infect · score 0.11
sebaceous of Jadassohn nevus · score 0.05
squamous cell carcinoma · score 0.04
viral disease · score 0.04
Barrett's esophagus · score 0.04
esophageal adenocarcinoma · score 0.03
neoplasm · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01824-F1	alphafold	PREDICTED	90.66	—

Amino-acid sequence (125 residues)

MDLMCKKMKH LWFFLLLVAA PRWVLSQLQL QESGPGLVKP SETLSLTCTV SGGSISSSSY YWGWIRQPPG KGLEWIGSIY YSGSTYYNPS LKSRVTISVD TSKNQFSLKL SSVTAADTAV YYCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards