Immunoglobulin heavy variable 4-59 (IGHV4-59)

About Immunoglobulin heavy variable 4-59

Immunoglobulin heavy variable 4-59 (IGHV4-59) is a protein from Homo sapiens identified by UniProt accession P01825, 116 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 4-59
UniProt accession	P01825
Gene	IGHV4-59
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
infection · score 0.11
infect · score 0.11
Barrett's esophagus · score 0.06
viral disease · score 0.04
squamous cell carcinoma · score 0.04
esophageal adenocarcinoma · score 0.04
sebaceous of Jadassohn nevus · score 0.04
neoplasm · score 0.02
Crohn's disease · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01825-F1	alphafold	PREDICTED	91.55	—

Amino-acid sequence (116 residues)

MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSETLSLT CTVSGGSISS YYWSWIRQPP GKGLEWIGYI YYSGSTNYNP SLKSRVTISV DTSKNQFSLK LSSVTAADTA VYYCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards