About Polymeric immunoglobulin receptor
Polymeric immunoglobulin receptor (PIGR) is a protein
from Homo sapiens identified by UniProt accession
P01833, 764 residues long.
MolForge cross-references it against 0 known binders and
344 disease associations.
Target properties
| Protein name | Polymeric immunoglobulin receptor |
|---|
| UniProt accession | P01833 |
|---|
| Gene | PIGR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 764 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (344)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.26
- lymphocyte count · score 0.21
- IGA glomerulonephritis · score 0.12
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.09
- immune deficiency, familial variable · score 0.09
- isolated agammaglobulinemia · score 0.09
- common variable immunodeficiency · score 0.08
- severe combined immunodeficiency due to CARD11 deficiency · score 0.08
- immunodeficiency, common variable, 4 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01833-F1 | alphafold | PREDICTED | 76.69 | — |
Amino-acid sequence (764 residues)
MLLFVLTCLL AVFPAISTKS PIFGPEEVNS VEGNSVSITC YYPPTSVNRH TRKYWCRQGA RGGCITLISS EGYVSSKYAG RANLTNFPEN GTFVVNIAQL SQDDSGRYKC GLGINSRGLS FDVSLEVSQG PGLLNDTKVY TVDLGRTVTI NCPFKTENAQ KRKSLYKQIG LYPVLVIDSS GYVNPNYTGR IRLDIQGTGQ LLFSVVINQL RLSDAGQYLC QAGDDSNSNK KNADLQVLKP EPELVYEDLR GSVTFHCALG PEVANVAKFL CRQSSGENCD VVVNTLGKRA PAFEGRILLN PQDKDGSFSV VITGLRKEDA GRYLCGAHSD GQLQEGSPIQ AWQLFVNEES TIPRSPTVVK GVAGGSVAVL CPYNRKESKS IKYWCLWEGA QNGRCPLLVD SEGWVKAQYE GRLSLLEEPG NGTFTVILNQ LTSRDAGFYW CLTNGDTLWR TTVEIKIIEG EPNLKVPGNV TAVLGETLKV PCHFPCKFSS YEKYWCKWNN TGCQALPSQD EGPSKAFVNC DENSRLVSLT LNLVTRADEG WYWCGVKQGH FYGETAAVYV AVEERKAAGS RDVSLAKADA APDEKVLDSG FREIENKAIQ DPRLFAEEKA VADTRDQADG SRASVDSGSS EEQGGSSRAL VSTLVPLGLV LAVGAVAVGV ARARHRKNVD RVSIRSYRTD ISMSDFENSR EFGANDNMGA SSITQETSLG GKEEFVATTE STTETKEPKK AKRSSKEEAE MAYKDFLLQS STVAAEAQDG PQEA
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