About Immunoglobulin heavy constant epsilon
Immunoglobulin heavy constant epsilon (IGHE) is a protein
from Homo sapiens identified by UniProt accession
P01854, 546 residues long.
MolForge cross-references it against 0 known binders and
1,293 disease associations.
Target properties
| Protein name | Immunoglobulin heavy constant epsilon |
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| UniProt accession | P01854 |
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| Gene | IGHE |
|---|
| Organism | Homo sapiens |
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| Length | 546 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | LOW |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1293)
Diseases linked to this target (Open Targets).
- asthma · score 0.62
- allergic asthma · score 0.59
- urticaria · score 0.58
- chronic idiopathic urticaria · score 0.56
- food allergy · score 0.56
- allergic disease · score 0.52
- sinusitis · score 0.50
- atopic eczema · score 0.48
- angioedema · score 0.44
- bullous pemphigoid · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01854-F1 | alphafold | PREDICTED | 76.53 | — |
Amino-acid sequence (546 residues)
ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG TTMTLPATTL TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK TFSVCSRDFT PPTVKILQSS CDGGGHFPPT IQLLCLVSGY TPGTINITWL EDGQVMDVDL STASTTQEGE LASTQSELTL SQKHWLSDRT YTCQVTYQGH TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL VVDLAPSKGT VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF MPEDISVQWL HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK DEFICRAVHE AASPSQTVQR AVSVNPGLAG GSAQSQRAPD RVLCHSGQQQ GLPRAAGGSV PHPRCHCGAG RADWPGPPEL DVCVEEAEGE APWTWTGLCI FAALFLLSVS YSAAITLLMV QRFLSATRQG RPQTSLDYTN VLQPHA
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