Immunoglobulin heavy constant gamma 1 (IGHG1)

About Immunoglobulin heavy constant gamma 1

Immunoglobulin heavy constant gamma 1 (IGHG1) is a protein from Homo sapiens identified by UniProt accession P01857, 399 residues long. MolForge cross-references it against 0 known binders and 201 disease associations.

Target properties

Protein name	Immunoglobulin heavy constant gamma 1
UniProt accession	P01857
Gene	IGHG1
Organism	Homo sapiens
Length	399 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (201)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
multiple myeloma · score 0.39
Systemic lupus erythematosus · score 0.37
systemic lupus erythematosus · score 0.37
immune deficiency, familial variable · score 0.08
common variable immunodeficiency · score 0.08
combined immunodeficiency with skin granulomas · score 0.07
hyper-IgM syndrome type 3 · score 0.07
classic Hodgkin lymphoma · score 0.07
Hodgkins lymphoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01857-F1	alphafold	PREDICTED	86.70	—

Amino-acid sequence (399 residues)

ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPEL QLEESCAEAQ DGELDGLWTT ITIFITLFLL SVCYSATVTF FKVKWIFSSV VDLKQTIIPD YRNMIGQGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards