Immunoglobulin heavy constant gamma 2 (IGHG2)

About Immunoglobulin heavy constant gamma 2

Immunoglobulin heavy constant gamma 2 (IGHG2) is a protein from Homo sapiens identified by UniProt accession P01859, 395 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	Immunoglobulin heavy constant gamma 2
UniProt accession	P01859
Gene	IGHG2
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
recurrent infections associated with rare immunoglobulin isotypes deficiency · score 0.38
immune deficiency, familial variable · score 0.08
common variable immunodeficiency · score 0.08
combined immunodeficiency with skin granulomas · score 0.07
hyper-IgM syndrome type 3 · score 0.07
classic Hodgkin lymphoma · score 0.07
Hodgkins lymphoma · score 0.07
severe combined immunodeficiency due to CARD11 deficiency · score 0.07
BENTA disease · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01859-F1	alphafold	PREDICTED	87.36	—

Amino-acid sequence (395 residues)

ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER KCCVECPPCP APPVAGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTFR VVSVLTVVHQ DWLNGKEYKC KVSNKGLPAP IEKTISKTKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDISVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPELQLEE SCAEAQDGEL DGLWTTITIF ITLFLLSVCY SATITFFKVK WIFSSVVDLK QTIVPDYRNM IRQGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards