Immunoglobulin heavy constant mu (IGHM)

About Immunoglobulin heavy constant mu

Immunoglobulin heavy constant mu (IGHM) is a protein from Homo sapiens identified by UniProt accession P01871, 474 residues long. MolForge cross-references it against 0 known binders and 315 disease associations.

Target properties

Protein name	Immunoglobulin heavy constant mu
UniProt accession	P01871
Gene	IGHM
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (315)

Diseases linked to this target (Open Targets).

agammaglobulinemia · score 0.46
isolated agammaglobulinemia · score 0.39
autosomal agammaglobulinemia · score 0.38
autoimmune disease · score 0.10
classic Hodgkin lymphoma · score 0.10
Hodgkins lymphoma · score 0.10
BENTA disease · score 0.09
immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia · score 0.09
combined immunodeficiency with skin granulomas · score 0.09
C1 inhibitor deficiency · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01871-F1	alphafold	PREDICTED	85.43	—

Amino-acid sequence (474 residues)

GSASAPTLFP LVSCENSPSD TSSVAVGCLA QDFLPDSITF SWKYKNNSDI SSTRGFPSVL RGGKYAATSQ VLLPSKDVMQ GTDEHVVCKV QHPNGNKEKN VPLPVIAELP PKVSVFVPPR DGFFGNPRKS KLICQATGFS PRQIQVSWLR EGKQVGSGVT TDQVQAEAKE SGPTTYKVTS TLTIKESDWL GQSMFTCRVD HRGLTFQQNA SSMCVPDQDT AIRVFAIPPS FASIFLTKST KLTCLVTDLT TYDSVTISWT RQNGEAVKTH TNISESHPNA TFSAVGEASI CEDDWNSGER FTCTVTHTDL PSPLKQTISR PKGVALHRPD VYLLPPAREQ LNLRESATIT CLVTGFSPAD VFVQWMQRGQ PLSPEKYVTS APMPEPQAPG RYFAHSILTV SEEEWNTGET YTCVVAHEAL PNRVTERTVD KSTEGEVSAD EEGFENLWAT ASTFIVLFLL SLFYSTTVTL FKVK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards