Immunoglobulin heavy constant alpha 1 (IGHA1)

About Immunoglobulin heavy constant alpha 1

Immunoglobulin heavy constant alpha 1 (IGHA1) is a protein from Homo sapiens identified by UniProt accession P01876, 398 residues long. MolForge cross-references it against 0 known binders and 437 disease associations.

Target properties

Protein name	Immunoglobulin heavy constant alpha 1
UniProt accession	P01876
Gene	IGHA1
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (437)

Diseases linked to this target (Open Targets).

IGA glomerulonephritis · score 0.12
chronic kidney disease · score 0.10
Rheumatoid arthritis · score 0.09
hepatocellular carcinoma · score 0.09
ulcerative colitis · score 0.08
inflammatory bowel disease · score 0.08
isolated agammaglobulinemia · score 0.08
sebaceous of Jadassohn nevus · score 0.07
squamous cell carcinoma · score 0.07
immunodeficiency 35 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01876-F1	alphafold	PREDICTED	81.85	—

Amino-acid sequence (398 residues)

ASPTSPKVFP LSLCSTQPDG NVVIACLVQG FFPQEPLSVT WSESGQGVTA RNFPPSQDAS GDLYTTSSQL TLPATQCLAG KSVTCHVKHY TNPSQDVTVP CPVPSTPPTP SPSTPPTPSP SCCHPRLSLH RPALEDLLLG SEANLTCTLT GLRDASGVTF TWTPSSGKSA VQGPPERDLC GCYSVSSVLP GCAEPWNHGK TFTCTAAYPE SKTPLTATLS KSGNTFRPEV HLLPPPSEEL ALNELVTLTC LARGFSPKDV LVRWLQGSQE LPREKYLTWA SRQEPSQGTT TFAVTSILRV AAEDWKKGDT FSCMVGHEAL PLAFTQKTID RLADWQMPPP YVVLDLPQET LEEETPGANL WPTTITFLTL FLLSLFYSTA LTVTSVRGPS GNREGPQY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards