Immunoglobulin heavy constant alpha 2 (IGHA2)

About Immunoglobulin heavy constant alpha 2

Immunoglobulin heavy constant alpha 2 (IGHA2) is a protein from Homo sapiens identified by UniProt accession P01877, 391 residues long. MolForge cross-references it against 0 known binders and 229 disease associations.

Target properties

Protein name	Immunoglobulin heavy constant alpha 2
UniProt accession	P01877
Gene	IGHA2
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (229)

Diseases linked to this target (Open Targets).

isolated agammaglobulinemia · score 0.08
immunodeficiency 35 · score 0.07
common variable immunodeficiency · score 0.07
Chronic mucocutaneous candidosis · score 0.07
varicella, severe recurrent · score 0.07
severe combined immunodeficiency due to CARD11 deficiency · score 0.07
severe combined immunodeficiency due to CTPS1 deficiency · score 0.07
candidiasis, familial, 4 · score 0.07
hyper-IgM syndrome type 3 · score 0.07
ICF syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01877-F1	alphafold	PREDICTED	82.98	—

Amino-acid sequence (391 residues)

ASPTSPKVFP LSLDSTPQDG NVVVACLVQG FFPQEPLSVT WSESGQNVTA RNFPPSQDAS GDLYTTSSQL TLPATQCPDG KSVTCHVKHY TNSSQDVTVP CRVPPPPPCC HPRLSLHRPA LEDLLLGSEA NLTCTLTGLR DASGATFTWT PSSGKSAVQG PPERDLCGCY SVSSVLPGCA QPWNHGETFT CTAAHPELKT PLTANITKSG NTFRPEVHLL PPPSEELALN ELVTLTCLAR GFSPKDVLVR WLQGSQELPR EKYLTWASRQ EPSQGTTTYA VTSILRVAAE DWKKGETFSC MVGHEALPLA FTQKTIDRMA GSCCVADWQM PPPYVVLDLP QETLEEETPG ANLWPTTITF LTLFLLSLFY STALTVTSVR GPSGKREGPQ Y

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards