About HLA class II histocompatibility antigen, DQ alpha 1 chain
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) is a protein
from Homo sapiens identified by UniProt accession
P01909, 254 residues long.
MolForge cross-references it against 0 known binders and
435 disease associations.
Target properties
| Protein name | HLA class II histocompatibility antigen, DQ alpha 1 chain |
|---|
| UniProt accession | P01909 |
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| Gene | HLA-DQA1 |
|---|
| Organism | Homo sapiens |
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| Length | 254 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (435)
Diseases linked to this target (Open Targets).
- asthma · score 0.38
- blood protein measurement · score 0.34
- type 1 diabetes mellitus · score 0.28
- rheumatoid arthritis · score 0.28
- autoimmune thyroid disease · score 0.28
- hemoglobin measurement · score 0.27
- Nasal Cavity Polyp · score 0.27
- ulcerative colitis · score 0.26
- adult onset asthma · score 0.25
- erythrocyte count · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01909-F1 | alphafold | PREDICTED | 87.91 | — |
Amino-acid sequence (254 residues)
MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH EFDGDEQFYV DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK RSNSTAATNE VPEVTVFSKS PVTLGQPNIL ICLVDNIFPP VVNITWLSNG HSVTEGVSET SFLSKSDHSF FKISYLTLLP SAEESYDCKV EHWGLDKPLL KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR GLRSVGASRH QGPL
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