About Hemoglobin subunit zeta
Hemoglobin subunit zeta (HBZ) is a protein
from Homo sapiens identified by UniProt accession
P02008, 142 residues long.
MolForge cross-references it against 0 known binders and
216 disease associations.
Target properties
| Protein name | Hemoglobin subunit zeta |
|---|
| UniProt accession | P02008 |
|---|
| Gene | HBZ |
|---|
| Organism | Homo sapiens |
|---|
| Length | 142 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (216)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.25
- mean corpuscular hemoglobin concentration · score 0.25
- mean corpuscular hemoglobin · score 0.24
- erythrocyte count · score 0.24
- red blood cell density measurement · score 0.18
- reticulocyte count · score 0.18
- Red cell distribution width · score 0.17
- reticulocyte measurement · score 0.15
- mean reticulocyte volume · score 0.15
- hemoglobin measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02008-F1 | alphafold | PREDICTED | 97.87 | — |
Amino-acid sequence (142 residues)
MSLTKTERTI IVSMWAKIST QADTIGTETL ERLFLSHPQT KTYFPHFDLH PGSAQLRAHG SKVVAAVGDA VKSIDDIGGA LSKLSELHAY ILRVDPVNFK LLSHCLLVTL AARFPADFTA EAHAAWDKFL SVVSSVLTEK YR
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