Hemoglobin subunit epsilon (HBE1)

About Hemoglobin subunit epsilon

Hemoglobin subunit epsilon (HBE1) is a protein from Homo sapiens identified by UniProt accession P02100, 147 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Hemoglobin subunit epsilon
UniProt accession	P02100
Gene	HBE1
Organism	Homo sapiens
Length	147 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

beta thalassemia · score 0.33
low grade glioma · score 0.18
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.15
glioblastoma multiforme · score 0.15
sensory perception of smell · score 0.14
malaria · score 0.12
mean corpuscular volume · score 0.10
Red cell distribution width · score 0.08
mean reticulocyte volume · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02100-F1	alphafold	PREDICTED	97.33	—

Amino-acid sequence (147 residues)

MVHFTAEEKA AVTSLWSKMN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS SPSAILGNPK VKAHGKKVLT SFGDAIKNMD NLKPAFAKLS ELHCDKLHVD PENFKLLGNV MVIILATHFG KEFTPEVQAA WQKLVSAVAI ALAHKYH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards