About Alpha-crystallin A chain
Alpha-crystallin A chain (CRYAA) is a protein
from Homo sapiens identified by UniProt accession
P02489, 173 residues long.
MolForge cross-references it against 0 known binders and
204 disease associations.
Target properties
| Protein name | Alpha-crystallin A chain |
|---|
| UniProt accession | P02489 |
|---|
| Gene | CRYAA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 173 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (204)
Diseases linked to this target (Open Targets).
- Cataract-microcornea syndrome · score 0.84
- Developmental cataract · score 0.57
- early-onset non-syndromic cataract · score 0.50
- refractive error measurement · score 0.43
- microphthalmia · score 0.39
- anterior segment dysgenesis · score 0.37
- total early-onset cataract · score 0.37
- early-onset anterior polar cataract · score 0.37
- early-onset nuclear cataract · score 0.37
- genetic disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02489-F1 | alphafold | PREDICTED | 74.70 | — |
Amino-acid sequence (173 residues)
MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ SLFRTVLDSG ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH NERQDDHGYI SREFHRRYRL PSNVDQSALS CSLSADGMLT FCGPKIQTGL DATHAERAIP VSREEKPTSA PSS
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