About Alpha-crystallin B chain
Alpha-crystallin B chain (CRYAB) is a protein
from Homo sapiens identified by UniProt accession
P02511, 175 residues long.
MolForge cross-references it against 0 known binders and
483 disease associations.
Target properties
| Protein name | Alpha-crystallin B chain |
|---|
| UniProt accession | P02511 |
|---|
| Gene | CRYAB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 175 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (483)
Diseases linked to this target (Open Targets).
- myofibrillar myopathy 2 · score 0.76
- dilated cardiomyopathy 1II · score 0.73
- Posterior polar cataract · score 0.69
- cataract 16 multiple types · score 0.68
- fatal infantile hypertonic myofibrillar myopathy · score 0.67
- Partial congenital cataract · score 0.56
- early-onset non-syndromic cataract · score 0.44
- Developmental cataract · score 0.42
- Alpha-B crystallin-related late-onset distal myopathy · score 0.38
- familial isolated dilated cardiomyopathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02511-F1 | alphafold | PREDICTED | 75.78 | — |
Amino-acid sequence (175 residues)
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK
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