About Keratin, type I cytoskeletal 14
Keratin, type I cytoskeletal 14 (KRT14) is a protein
from Homo sapiens identified by UniProt accession
P02533, 472 residues long.
MolForge cross-references it against 0 known binders and
507 disease associations.
Target properties
| Protein name | Keratin, type I cytoskeletal 14 |
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| UniProt accession | P02533 |
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| Gene | KRT14 |
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| Organism | Homo sapiens |
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| Length | 472 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (507)
Diseases linked to this target (Open Targets).
- Epidermolysis bullosa simplex, Dowling-Meara type · score 0.82
- Localized epidermolysis bullosa simplex · score 0.81
- Generalized epidermolysis bullosa simplex, non-Dowling-Meara type · score 0.81
- epidermolysis bullosa simplex 1C, localized · score 0.80
- epidermolysis bullosa simplex 1A, generalized severe · score 0.80
- epidermolysis bullosa simplex 1B, generalized intermediate · score 0.75
- Naegeli-Franceschetti-Jadassohn syndrome · score 0.75
- KRT14-related epidermolysis bullosa simplex · score 0.74
- dermatopathia pigmentosa reticularis · score 0.74
- epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive · score 0.73
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02533-F1 | alphafold | PREDICTED | 73.24 | — |
Amino-acid sequence (472 residues)
MTTCSRQFTS SSSMKGSCGI GGGIGGGSSR ISSVLAGGSC RAPSTYGGGL SVSSSRFSSG GACGLGGGYG GGFSSSSSSF GSGFGGGYGG GLGAGLGGGF GGGFAGGDGL LVGSEKVTMQ NLNDRLASYL DKVRALEEAN ADLEVKIRDW YQRQRPAEIK DYSPYFKTIE DLRNKILTAT VDNANVLLQI DNARLAADDF RTKYETELNL RMSVEADING LRRVLDELTL ARADLEMQIE SLKEELAYLK KNHEEEMNAL RGQVGGDVNV EMDAAPGVDL SRILNEMRDQ YEKMAEKNRK DAEEWFFTKT EELNREVATN SELVQSGKSE ISELRRTMQN LEIELQSQLS MKASLENSLE ETKGRYCMQL AQIQEMIGSV EEQLAQLRCE MEQQNQEYKI LLDVKTRLEQ EIATYRRLLE GEDAHLSSSQ FSSGSQSSRD VTSSSRQIRT KVMDVHDGKV VSTHEQVLRT KN
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