About Prelamin-A/C
Prelamin-A/C (LMNA) is a protein
from Homo sapiens identified by UniProt accession
P02545, 664 residues long.
MolForge cross-references it against 0 known binders and
1,252 disease associations.
Target properties
| Protein name | Prelamin-A/C |
|---|
| UniProt accession | P02545 |
|---|
| Gene | LMNA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 664 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1252)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy · score 0.86
- Emery-Dreifuss muscular dystrophy 2, autosomal dominant · score 0.86
- familial partial lipodystrophy, Dunnigan type · score 0.86
- Hutchinson-Gilford progeria syndrome · score 0.85
- congenital muscular dystrophy due to LMNA mutation · score 0.81
- dilated cardiomyopathy 1A · score 0.78
- mandibuloacral dysplasia with type A lipodystrophy · score 0.78
- Charcot-Marie-Tooth disease type 2B1 · score 0.77
- dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome · score 0.76
- heart-hand syndrome, Slovenian type · score 0.74
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02545-F1 | alphafold | PREDICTED | 76.37 | — |
Amino-acid sequence (664 residues)
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQTQ GGGSVTKKRK LESTESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT YRFPPKFTLK AGQVVTIWAA GAGATHSPPT DLVWKAQNTW GCGNSLRTAL INSTGEEVAM RKLVRSVTVV EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA SGSGAQVGGP ISSGSSASSV TVTRSYRSVG GSGGGSFGDN LVTRSYLLGN SSPRTQSPQN CSIM
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