Apolipoprotein A-I (APOA1)

About Apolipoprotein A-I

Apolipoprotein A-I (APOA1) is a protein from Homo sapiens identified by UniProt accession P02647, 267 residues long. MolForge cross-references it against 0 known binders and 987 disease associations.

Target properties

Protein name	Apolipoprotein A-I
UniProt accession	P02647
Gene	APOA1
Organism	Homo sapiens
Length	267 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (987)

Diseases linked to this target (Open Targets).

familial visceral amyloidosis · score 0.78
hypoalphalipoproteinemia, primary, 2 · score 0.74
Familial renal amyloidosis · score 0.71
high density lipoprotein cholesterol measurement · score 0.62
apolipoprotein A-I deficiency · score 0.60
hypoalphalipoproteinemia, primary, 2, intermediate · score 0.59
lipoprotein measurement · score 0.58
concentration of large HDL particles measurement · score 0.55
cholesteryl ester measurement · score 0.55
phospholipids:total lipids ratio · score 0.52

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02647-F1	alphafold	PREDICTED	73.56	—

Amino-acid sequence (267 residues)

MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG RDYVSQFEGS ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL QEGARQKLHE LQEKLSPLGE EMRDRARAHV DALRTHLAPY SDELRQRLAA RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ GLLPVLESFK VSFLSALEEY TKKLNTQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards