Apolipoprotein E (APOE)

About Apolipoprotein E

Apolipoprotein E (APOE) is a protein from Homo sapiens identified by UniProt accession P02649, 317 residues long. MolForge cross-references it against 0 known binders and 1,518 disease associations.

Target properties

Protein name	Apolipoprotein E
UniProt accession	P02649
Gene	APOE
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02649-F1	alphafold	PREDICTED	75.47	—

Amino-acid sequence (317 residues)

MKVLWAALLV TFLAGCQAKV EQAVETEPEP ELRQQTEWQS GQRWELALGR FWDYLRWVQT LSEQVQEELL SSQVTQELRA LMDETMKELK AYKSELEEQL TPVAEETRAR LSKELQAAQA RLGADMEDVC GRLVQYRGEV QAMLGQSTEE LRVRLASHLR KLRKRLLRDA DDLQKRLAVY QAGAREGAER GLSAIRERLG PLVEQGRVRA ATVGSLAGQP LQERAQAWGE RLRARMEEMG SRTRDRLDEV KEQVAEVRAK LEEQAQQIRL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK VQAAVGTSAA PVPSDNH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards