Apolipoprotein A-II (APOA2)

About Apolipoprotein A-II

Apolipoprotein A-II (APOA2) is a protein from Homo sapiens identified by UniProt accession P02652, 100 residues long. MolForge cross-references it against 0 known binders and 210 disease associations.

Target properties

Protein name	Apolipoprotein A-II
UniProt accession	P02652
Gene	APOA2
Organism	Homo sapiens
Length	100 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (210)

Diseases linked to this target (Open Targets).

amyloidosis · score 0.38
apolipoprotein A-II amyloidosis · score 0.37
hypercholesterolemia, familial, 1 · score 0.33
cutaneous melanoma · score 0.23
head and neck squamous cell carcinoma · score 0.15
platelet count · score 0.10
endometrial cancer · score 0.09
mean platelet volume · score 0.09
familial primary localized cutaneous amyloidosis · score 0.08
myocardial infarction · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02652-F1	alphafold	PREDICTED	75.67	—

Amino-acid sequence (100 residues)

MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME KVKSPELQAE AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards