Apolipoprotein C-I (APOC1)

About Apolipoprotein C-I

Apolipoprotein C-I (APOC1) is a protein from Homo sapiens identified by UniProt accession P02654, 83 residues long. MolForge cross-references it against 0 known binders and 489 disease associations.

Target properties

Protein name	Apolipoprotein C-I
UniProt accession	P02654
Gene	APOC1
Organism	Homo sapiens
Length	83 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (489)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.35
cholesterol embolism · score 0.33
Alzheimer disease · score 0.32
blood protein measurement · score 0.32
sex hormone-binding globulin measurement · score 0.30
low density lipoprotein cholesterol measurement · score 0.29
high density lipoprotein cholesterol measurement · score 0.29
vitamin D measurement · score 0.29
total cholesterol measurement · score 0.29
BMI-adjusted waist-hip ratio · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02654-F1	alphafold	PREDICTED	70.66	—

Amino-acid sequence (83 residues)

MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards