About Apolipoprotein C-II
Apolipoprotein C-II (APOC2) is a protein
from Homo sapiens identified by UniProt accession
P02655, 101 residues long.
MolForge cross-references it against 0 known binders and
221 disease associations.
Target properties
| Protein name | Apolipoprotein C-II |
|---|
| UniProt accession | P02655 |
|---|
| Gene | APOC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 101 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (221)
Diseases linked to this target (Open Targets).
- familial apolipoprotein C-II deficiency · score 0.75
- familial chylomicronemia syndrome · score 0.55
- Abnormality of the cardiovascular system · score 0.45
- Hyperlipoproteinemia type 1 · score 0.38
- amyloidosis · score 0.38
- body height · score 0.18
- blood protein measurement · score 0.12
- hypertriglyceridemia 2 · score 0.10
- cholesterol-ester transfer protein deficiency · score 0.08
- high density lipoprotein cholesterol measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02655-F1 | alphafold | PREDICTED | 65.89 | — |
Amino-acid sequence (101 residues)
MGTRLLPALF LVLLVLGFEV QGTQQPQQDE MPSPTFLTQV KESLSSYWES AKTAAQNLYE KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE E
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