About Fibrinogen beta chain
Fibrinogen beta chain (FGB) is a protein
from Homo sapiens identified by UniProt accession
P02675, 491 residues long.
MolForge cross-references it against 0 known binders and
271 disease associations.
Target properties
| Protein name | Fibrinogen beta chain |
|---|
| UniProt accession | P02675 |
|---|
| Gene | FGB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 491 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (271)
Diseases linked to this target (Open Targets).
- congenital afibrinogenemia · score 0.79
- Familial afibrinogenemia · score 0.77
- familial dysfibrinogenemia · score 0.70
- cancer · score 0.59
- hemorrhage · score 0.56
- familial hypodysfibrinogenemia · score 0.54
- Hypofibrinogenemia · score 0.53
- Noonan syndrome · score 0.53
- fibrinogen measurement · score 0.51
- hypertrophic cardiomyopathy · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02675-F1 | alphafold | PREDICTED | 84.07 | — |
Amino-acid sequence (491 residues)
MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM SMKIRPFFPQ Q
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