About Acetylcholine receptor subunit alpha
Acetylcholine receptor subunit alpha (CHRNA1) is a protein
from Homo sapiens identified by UniProt accession
P02708, 457 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Acetylcholine receptor subunit alpha |
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| UniProt accession | P02708 |
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| Gene | CHRNA1 |
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| Organism | Homo sapiens |
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| Length | 457 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (147)
Diseases linked to this target (Open Targets).
- Postsynaptic congenital myasthenic syndromes · score 0.82
- Congenital myasthenic syndromes · score 0.81
- lethal multiple pterygium syndrome · score 0.77
- post-operative sign or symptom · score 0.58
- pain · score 0.55
- acute respiratory distress syndrome · score 0.53
- pregnancy · score 0.50
- severe acute respiratory syndrome · score 0.50
- intracranial hypertension · score 0.46
- rotator cuff tear · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02708-F1 | alphafold | PREDICTED | 84.03 | — |
Amino-acid sequence (457 residues)
MEPWPLLLLF SLCSAGLVLG SEHETRLVAK LFKDYSSVVR PVEDHRQVVE VTVGLQLIQL INVDEVNQIV TTNVRLKQQW VDYNLKWNPD DYGGVKKIHI PSEKIWRPDL VLYNNADGDF AIVKFTKVLL QYTGHITWTP PAIFKSYCEI IVTHFPFDEQ NCSMKLGTWT YDGSVVAINP ESDQPDLSNF MESGEWVIKE SRGWKHSVTY SCCPDTPYLD ITYHFVMQRL PLYFIVNVII PCLLFSFLTG LVFYLPTDSG EKMTLSISVL LSLTVFLLVI VELIPSTSSA VPLIGKYMLF TMVFVIASII ITVIVINTHH RSPSTHVMPN WVRKVFIDTI PNIMFFSTMK RPSREKQDKK IFTEDIDISD ISGKPGPPPM GFHSPLIKHP EVKSAIEGIK YIAETMKSDQ ESNNAAAEWK YVAMVMDHIL LGVFMLVCII GTLAVFAGRL IELNQQG
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