About Serum amyloid P-component
Serum amyloid P-component (APCS) is a protein
from Homo sapiens identified by UniProt accession
P02743, 223 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | Serum amyloid P-component |
|---|
| UniProt accession | P02743 |
|---|
| Gene | APCS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 223 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (176)
Diseases linked to this target (Open Targets).
- C-reactive protein measurement · score 0.40
- AL amyloidosis · score 0.37
- blood phosphate measurement · score 0.34
- blood protein measurement · score 0.31
- serum amyloid P-component measurement · score 0.23
- phosphate measurement · score 0.22
- mathematical ability · score 0.21
- self reported educational attainment · score 0.21
- response to selective serotonin reuptake inhibitor · score 0.14
- low density lipoprotein cholesterol measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02743-F1 | alphafold | PREDICTED | 94.42 | — |
Amino-acid sequence (223 residues)
MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV
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