About Complement C1q subcomponent subunit A
Complement C1q subcomponent subunit A (C1QA) is a protein
from Homo sapiens identified by UniProt accession
P02745, 245 residues long.
MolForge cross-references it against 0 known binders and
251 disease associations.
Target properties
| Protein name | Complement C1q subcomponent subunit A |
|---|
| UniProt accession | P02745 |
|---|
| Gene | C1QA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 245 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (251)
Diseases linked to this target (Open Targets).
- C1Q deficiency · score 0.62
- immunodeficiency due to a classical component pathway complement deficiency · score 0.55
- C1Q deficiency 1 · score 0.44
- blood protein measurement · score 0.22
- tumor necrosis factor beta measurement · score 0.20
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.16
- infection · score 0.09
- infect · score 0.09
- schizophrenia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02745-F1 | alphafold | PREDICTED | 82.62 | — |
Amino-acid sequence (245 residues)
MEGPRGWLVL CVLAISLASM VTEDLCRAPD GKKGEAGRPG RRGRPGLKGE QGEPGAPGIR TGIQGLKGDQ GEPGPSGNPG KVGYPGPSGP LGARGIPGIK GTKGSPGNIK DQPRPAFSAI RRNPPMGGNV VIFDTVITNQ EEPYQNHSGR FVCTVPGYYY FTFQVLSQWE ICLSIVSSSR GQVRRSLGFC DTTNKGLFQV VSGGMVLQLQ QGDQVWVEKD PKKGHIYQGS EADSVFSGFL IFPSA
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