Complement C1q subcomponent subunit C (C1QC)

About Complement C1q subcomponent subunit C

Complement C1q subcomponent subunit C (C1QC) is a protein from Homo sapiens identified by UniProt accession P02747, 245 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Complement C1q subcomponent subunit C
UniProt accession	P02747
Gene	C1QC
Organism	Homo sapiens
Length	245 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

C1Q deficiency · score 0.62
immunodeficiency due to a classical component pathway complement deficiency · score 0.55
neurodegenerative disease · score 0.54
blood protein measurement · score 0.36
genetic disorder · score 0.18
cutaneous melanoma · score 0.16
MODY · score 0.08
neuroinflammatory disorder · score 0.07
diabetes mellitus, transient neonatal, 2 · score 0.05
ulna metaphyseal dysplasia syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02747-F1	alphafold	PREDICTED	80.54	—

Amino-acid sequence (245 residues)

MDVGPSSLPH LGLKLLLLLL LLPLRGQANT GCYGIPGMPG LPGAPGKDGY DGLPGPKGEP GIPAIPGIRG PKGQKGEPGL PGHPGKNGPM GPPGMPGVPG PMGIPGEPGE EGRYKQKFQS VFTVTRQTHQ PPAPNSLIRF NAVLTNPQGD YDTSTGKFTC KVPGLYYFVY HASHTANLCV LLYRSGVKVV TFCGHTSKTN QVNSGGVLLR LQVGEEVWLA VNDYYDMVGI QGSDSVFSGF LLFPD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards