Beta-2-glycoprotein 1 (APOH)

About Beta-2-glycoprotein 1

Beta-2-glycoprotein 1 (APOH) is a protein from Homo sapiens identified by UniProt accession P02749, 345 residues long. MolForge cross-references it against 0 known binders and 419 disease associations.

Target properties

Protein name	Beta-2-glycoprotein 1
UniProt accession	P02749
Gene	APOH
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (419)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.50
platelet count · score 0.49
sex hormone-binding globulin measurement · score 0.49
blood protein measurement · score 0.48
triglyceride measurement · score 0.47
serum alanine aminotransferase measurement · score 0.47
total cholesterol measurement · score 0.46
C-reactive protein measurement · score 0.44
platelet crit · score 0.44
apolipoprotein B measurement · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02749-F1	alphafold	PREDICTED	93.10	—

Amino-acid sequence (345 residues)

MISPVLILFS SFLCHVAIAG RTCPKPDDLP FSTVVPLKTF YEPGEEITYS CKPGYVSRGG MRKFICPLTG LWPINTLKCT PRVCPFAGIL ENGAVRYTTF EYPNTISFSC NTGFYLNGAD SAKCTEEGKW SPELPVCAPI ICPPPSIPTF ATLRVYKPSA GNNSLYRDTA VFECLPQHAM FGNDTITCTT HGNWTKLPEC REVKCPFPSR PDNGFVNYPA KPTLYYKDKA TFGCHDGYSL DGPEEIECTK LGNWSAMPSC KASCKVPVKK ATVVYQGERV KIQEKFKNGM LHGDKVSFFC KNKEKKCSYT EDAQCIDGTI EVPKCFKEHS SLAFWKTDAS DVKPC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards