Alpha-2-HS-glycoprotein (AHSG)

About Alpha-2-HS-glycoprotein

Alpha-2-HS-glycoprotein (AHSG) is a protein from Homo sapiens identified by UniProt accession P02765, 367 residues long. MolForge cross-references it against 0 known binders and 530 disease associations.

Target properties

Protein name	Alpha-2-HS-glycoprotein
UniProt accession	P02765
Gene	AHSG
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (530)

Diseases linked to this target (Open Targets).

Alopecia-intellectual disability syndrome · score 0.61
nephrolithiasis susceptibility caused by SLC26A1 · score 0.42
calcium oxalate urolithiasis · score 0.42
blood protein measurement · score 0.39
calcium measurement · score 0.38
alpha-2-HS-glycoprotein measurement · score 0.37
protein measurement · score 0.32
alkaline phosphatase measurement · score 0.23
neurodegenerative disease · score 0.20
esophageal cancer · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02765-F1	alphafold	PREDICTED	76.14	—

Amino-acid sequence (367 residues)

MKSLVLLLCL AQLWGCHSAP HGPGLIYRQP NCDDPETEEA ALVAIDYINQ NLPWGYKHTL NQIDEVKVWP QQPSGELFEI EIDTLETTCH VLDPTPVARC SVRQLKEHAV EGDCDFQLLK LDGKFSVVYA KCDSSPDSAE DVRKVCQDCP LLAPLNDTRV VHAAKAALAA FNAQNNGSNF QLEEISRAQL VPLPPSTYVE FTVSGTDCVA KEATEAAKCN LLAEKQYGFC KATLSEKLGG AEVAVTCMVF QTQPVSSQPQ PEGANEAVPT PVVDPDAPPS PPLGAPGLPP AGSPPDSHVL LAAPPGHQLH RAHYDLRHTF MGVVSLGSPS GEVSHPRKTR TVVQPSVGAA AGPVVPPCPG RIRHFKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards